Gram-scale preparation of negative-type liquid crystals with a CF₂CF₂-carbocycle unit via an improved short-step synthetic protocol

• Tatsuya Kumon,
• Shohei Hashishita,
• Takumi Kida,
• Shigeyuki Yamada,
• Takashi Ishihara and
• Tsutomu Konno

Beilstein J. Org. Chem. 2018, 14, 148–154, doi:10.3762/bjoc.14.10

• ; tetrafluorinated cyclohexadiene; tetrafluorinated cyclohexane; Introduction Fluorine-containing organic compounds have attracted much attention in various areas, such as the medicinal, agrochemical, and materials science fields [1][2][3], due to the unique characteristics of the fluorine atom [4][5][6]. It is

• determined to be the cis-isomer in both cases. Conclusion In summary, we demonstrated the efficient short-step, gram-scale preparation of tetrafluorinated cyclohexadiene or cyclohexane derivatives, which are very promising negative-type LC molecules, starting from commercially available dimethyl 2,2,3,3